Quantitative description of genetic diversity of some Nigerian indigenous goat population is scanty. Biochemical characters were used to determine the relationship among Red Sokoto, Sahel and West Africa Dwarf .Equal numbers of breed (Red Sokoto, Sahel and WAD from Sokoto, Borno and Ogun state were sampled for blood biochemical polymorphic traits (Haemoglobin (Hb), Transferrin (Tf) and Carbonic anhydrase (CA) loci) using a total of 900 goats. Generally, genetic distance analysis based blood biochemical indicators indicated closer relationship between the Red Sokoto and Sahel with both breeds being distant from the WAD. Also there were high degrees of similarity in genetic relationship among the three breeds indicating a high rate of dilution of the breeds which may lead to loss of genetic resources. It is recommended that efforts should be made to conserve genetic resources and reduce dilution of the gene pool through indiscriminate mating among the breeds.
