Quinazoline nucleosides are heterocyclic compounds of great importance in medicinal chemistry due to their diverse biological activities, including anticancer, antimicrobial, and anti-inflammatory properties. This article aims to review the methods for the synthesis and characterization of some nucleosides 6,7-Dimethoxyquinazoline-2,4-(1H,3H)-Dione, focusing on the reactions between quinazolinones and sugars to produce alpha- and beta-analogues of these nucleosides. This work is expected to contribute to the field of medicinal chemistry and future drug development. The 6,7-Dimethoxy 2,4-(1H, 3H)-quinazolinone (2) was reflexed with HMDS from 1day using the Vorbruggen’s silylation method. The trimethyl silylquinazolinone (3) was reacted with 1-O-acetyl- 2,3,5-tri-O-benzoyl-D-ribofuranose (4) afford three protected nucleosides (5,6 and 7) respectively. Debenzoylation of each of protected nucleosides by sodium metal in dry methanol affore the free nucleosides (8,9 and 10) respectively in good yield . The new synthesized compounds were characterized using the well-known spectroscopic (IR, 1HNMR, 13CNMR and mass spectroscopy).
