Mushrooms are high in nutrients, including proteins, minerals, vitamins, and bioactive components like phenolic compounds, terpenes, steroids and polysaccharides. The demand for cultivating mushrooms is growing day by day, as people become more aware of its palatability and high nutritional worth. But diseases cause heavy losses in commercial mushroom farms worldwide. The output and productivity of commercial mushroom farming can be severely harmed by disease outbreaks. Intensive cultivation of edible mushrooms is commonly afflicted by fungal, bacterial, and viral infections which frequently result in significant production losses. Beside these, a number of non-infectious physiological disorders are found to occur frequently that reduce the yield of the crop. Warm temperatures, high humidity, and a low aeration rate, which are typical circumstances for mushroom growth, encourage the spread of these illnesses. Due to a short term crops, chemicals management of mushroom diseases are not recommended owing to residual dangers. As mushroom cultivation is a young, developing sector that is flourishing all over the world today. There is utmost necessary to pay greater attention to healthy mushroom production and proper disease management. In this article we described fungal, bacterial and viral diseases, several actinomycetes moulds and contaminants and non-infectious physiologic disorders that frequently occur in mushroom production farms. General and specific management practices of these diseases and disorders during mushroom production are also described.