Drugs use and abuse among the adolescents affect the individual, family and community in Rwanda. However, the current arsenal of effective approaches to increase adherence to risk-reduction strategies and communication with Rwandan adolescents remains insufficient. Despite the potential protective role of parent-adolescent communication (PAC) program about sexual and drugs use behavior, much remains unknown about the process and contexts in which these communication encounters occur in Rwanda. Community-based participatory research (CBPR) is an approach to research and evaluation that is receiving increased attention in the field of health and environmental research. The present study explains the application of the approach to research and evaluation with parent-adolescent communication (PAC) program about drugs use in Rubavu District, Rwanda. The researcher primary purpose is to illustrate the key elements that contributed to effective collaboration among PAC facilitators, local researcher, parents and their children adolescents in the conduct of the study. In the present paper the focus is not research findings but on the research process. The researchers'aim to illustrate the practices of CBPR, so they can be analysed, further developed, and effectively facilitate replication of the process by other researchers who are interested in applying the approach to culturally responsible PAC intervention in diversity of community context.