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Synthesis and biological activities of analogs of aryl tetralone

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Author: 
Chaitramallu, M., Devaraju kesagodu, Dakshayini chandra shekarachar and Dr. Ranjini
Abstract: 

The aryl tetralone as potential antimitotic agents were synthesized in four step reactions using Grignard reagent. The first step is the synthesis of trimethoxy phenyl naphthol (2a-f) by the reaction of substituted tetralone with 3, 4, 5-trimethoxy 1-bromobenzene in magnesium metal using tetrahydrofuran as a solvent. The resulted phenyl naphthol was hydrogenated to give phenyl tetralin 3(a-f). The substituted phenyl tetralone were prepared by the oxidation of trimethoxy phenyl tetralin 4(a-f). The structures of the synthesized compounds were confirmed by spectral and elemental analysis data. The synthesized compounds were also screened for their antidiabetic activity. It is noteworthy that compounds 4d possessed excellent antidiabetic activity, 4b and 4c showed considerable activity, and remaining 4a possessed least activity. Compound 4d was immense to show high antibacterial and antifungal activity against all bacterial and fungal strains compared with standard chloramphenicol and nystatin, respectively.

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