Call for Papers : Volume 15, Issue 05, May 2024, Open Access; Impact Factor; Peer Reviewed Journal; Fast Publication

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Study of the acute toxicity of the aqueous extract of tabernanthe iboga (baill.) (apocynacea) on wistar rats

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This study focused on the evaluation of Tabernanthe iboga (Baill.) acute toxicity. The lethal dose (LD50) was determined on Thirty-five Wistar rats using BERHENS and KARBER’s method. A total of seven batches of five animals including one control group were established and single doses of 392.1, 784, 71, 1000, 1570.5, 1750 and 2000 mg/kg were administered orally. The control group received distilled water. The results obtained allowed us to determine the LD50 at 1442.571 mg/kg of body weight. Therefore, Tabernanthe iboga could be classified as a low toxicity product.

Author: 
Mayindza Ekaghba, E. L., Boukandou Mounanga M. M., Mathouet, H., Mendene, H. F.1 and Mba Ndong, J. G.
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