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Pre-clinical evaluation of DCL2016 ointment on superficial burn wound healing in rats

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Author: 
Mahalaxmi Mohan, Joshi Amol, Mohammed Saad and Shishir Pande
Abstract: 

Objective: To evaluate the efficacy and safety of DCL2016 ointment on superficial burn wound healing in rats.
Materials and Methods: Animals were divided into five groups. Partial burn wound was inflicted on shaven back of anaesthetized rats by exposing it to hot water (72oC for 12sec). The wounds in the five groups of rats were treated topically with Silver sulfadiazine (SSD) 1%, DCL 2016 ointment with lead, DCL 2016 ointment without Lead, Only Lead and the control group was treated with castor oil base. Application of ointment was done till re-epithelization of skinor upto 21 days whichever was earlier.
Results: The percentage of wound contraction was significantly (p<0.05) increased in SSD, DCL2016 ointment with lead and only lead treated groups as compared to control groups. The period of re-epithelization was also significantly decreased in these groups as compared to control group. The Hb count was lower in only lead and DCL2016 with lead treated group as compared to control group. Histopathological results showed no signs of microscopic infection and hence showed better healing ability of the ointment. Determination of lead in blood by Atomic Absorption Spectrophotometer (AAS) indicated that the blood lead level in all groups were not significantly different as compared to control group animals.
Conclusion: Incorporation of lead within the said limits with DCL 2016 ointment shows enhanced healing process in superficial burn wounds in rats.

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