Paget’s disease of bone: case report

Paget's Disease of Bone (PDB), also described as Deforming Osteitis, is defined as a process of skeletal remodeling, of monostotic or polyostotic character, in which the affected bone itself undergoes an excessive resorption process, being replaced by a weakened tissue; that leads to a propensity for fractures and deformities. Its etiology is unknown, but environmental or hereditary factors, viral infections, and inflammatory processes have been related to the clinical expression of PDB. It is not a very rare disease, being the second in prevalence in relation to bone alterations, preceded only by osteoporosis. However, some aspects must be constantly remembered, especially what concerns PDB patients oral health. This is justified by the ossicleinvolvement of the maxillo-mandibular complex and care for invasive clinical management, since the elective treatment for PDB involves the use of bisphosphonates, which inthe current literature has been shown to be a potential causative agent of osteonecrosis. In this sense, the present article aims to present a clinical case report of a patient with PDB who was submitted to lower molar extraction, and to discuss the drug interactions, besides highlighting the main aspects of this disease, both in the systemic context and at the oral level.