QUICK RESPONSE

QUICK RESPONSE WHATSAPP ONLY

              

CATEGORIES

CERTIFICATE

COPYRIGHT AGREEMENT

 

Browse by Subject

  • Agricultural Sciences
  • Biology and Life Sciences
  • Chemistry & Chemical Engineering
  • Medicine, Health & Food
  • Physics
  • Materials Science
  • Mathematics & Statistics
  • Electrical & Computer Science
  • Earth, Energy & Environment
  • Architecture & Civil Engineering
  • Transportation & Logistics
  • Engineering & Technology
  • Economics & Management
  • Education
  • Social Sciences & Psychology
  • Arts, Literature & Linguistics

 

New-generation Antimalarial drugs

  • strict warning: Non-static method view::load() should not be called statically in /home4/vibu/public_html/journalajst.com/sites/all/modules/views/views.module on line 906.
  • strict warning: Declaration of views_handler_filter::options_validate() should be compatible with views_handler::options_validate($form, &$form_state) in /home4/vibu/public_html/journalajst.com/sites/all/modules/views/handlers/views_handler_filter.inc on line 607.
  • strict warning: Declaration of views_handler_filter::options_submit() should be compatible with views_handler::options_submit($form, &$form_state) in /home4/vibu/public_html/journalajst.com/sites/all/modules/views/handlers/views_handler_filter.inc on line 607.
  • strict warning: Declaration of views_handler_filter_boolean_operator::value_validate() should be compatible with views_handler_filter::value_validate($form, &$form_state) in /home4/vibu/public_html/journalajst.com/sites/all/modules/views/handlers/views_handler_filter_boolean_operator.inc on line 159.
  • strict warning: Declaration of views_plugin_row::options_validate() should be compatible with views_plugin::options_validate(&$form, &$form_state) in /home4/vibu/public_html/journalajst.com/sites/all/modules/views/plugins/views_plugin_row.inc on line 134.
  • strict warning: Declaration of views_plugin_row::options_submit() should be compatible with views_plugin::options_submit(&$form, &$form_state) in /home4/vibu/public_html/journalajst.com/sites/all/modules/views/plugins/views_plugin_row.inc on line 134.
  • strict warning: Non-static method view::load() should not be called statically in /home4/vibu/public_html/journalajst.com/sites/all/modules/views/views.module on line 906.
  • strict warning: Declaration of views_plugin_style_default::options() should be compatible with views_object::options() in /home4/vibu/public_html/journalajst.com/sites/all/modules/views/plugins/views_plugin_style_default.inc on line 24.
  • strict warning: Non-static method view::load() should not be called statically in /home4/vibu/public_html/journalajst.com/sites/all/modules/views/views.module on line 906.
  • strict warning: Non-static method view::load() should not be called statically in /home4/vibu/public_html/journalajst.com/sites/all/modules/views/views.module on line 906.
  • strict warning: Declaration of views_handler_argument::init() should be compatible with views_handler::init(&$view, $options) in /home4/vibu/public_html/journalajst.com/sites/all/modules/views/handlers/views_handler_argument.inc on line 744.
Author: 
Shaik Munwar and Chilamkuri Harshika
Abstract: 

Malaria is a disease that affects nearly 40% of the global population, and chemotherapy remains the mainstay of its control strategy. The global malaria situation is increasingly being exacerbated by the emergence of drug resistance to most of the available antimalarials, necessitating search for novel drugs. A recent rational approach of antimalarial drug design characterized as “covalent bitherapy” involves linking two molecules with individual intrinsic activity into a single agent, thus packaging dual-activity into a single hybrid molecule. Current research in this field seems to endorse hybrid molecules as the next-generation antimalarial drugs. If the selective toxicity of hybrid prodrugs can be demonstrated in vivo with good bioavailability at the target site in the parasite, it would offer various advantages including dosage compliance, minimized toxicity, ability to design better drug combinations, and cheaper preclinical evaluation while achieving the ultimate object of delaying or circumventing the development of resistance. This review is focused on several hybrid molecules that have been developed, with particular emphasis on those deemed to have high potential for development for clinical use.

EDITOR-IN-CHIEF

 

               Prof. Dr. ISMAIL YILDIRIM

CALL FOR PAPERS

CURRENT ISSUE

 

IMPACT FACTOR CERTIFICATE