New era in the treatment of hypertension: a drug metoprolol succinate used as a transdermal drug delivary system

The objective of the present investigation was to formulate (Controlled) and evaluate transdermal Drug delivery system of Metoprolol Succinate. The primary object is to overcome hepatic first pass metabolism and delivery of drug at controlled rate to achieve therapeutically effective drug level for a prolonged period of time of Metoprolol Succinate. On the basis of relatively better performance of various polymers, combination was selected for the fabrication of drug-reservoir. Propylene glycol as a plasticizer and PEG 400 as surfactant, Tween 80 and DMSO as a penetration enhancer were employed in fabrication of drug reservoir. Acetone and Ethanol is used as a solvent for dissolving the HPMC and ERS100 respectively. Medicated films were evaluated for physical & mechanical properties like Drug content, Folding endurance, Weight variation, % moisture content, %moisture uptake, and Thickness.