The aim of the present investigation was to develop and evaluate Econazole nitrate Microemulgel for a treatment of fungal infection. Microemulgel is isotropic mixtures of oil, water and emulsifying agent. Recently, Microemulgel has emerged as one of the most interesting topical preparation in the field of pharmaceutical sciences. The use of Microemulgel as a delivery system has several advantages such as ease of administration, increased residence time of drug at applied site, better drug release, good thermodynamic stability & higher transdermal permeability over conventional formulation. The objective of the study was to prepare Microemulgel of Econazole nitrate, using Carbopol 940 and HPMC [9004-65-3] as a gelling agent, oil phase, preservative, emulsifying agent and buffers was used as penetration enhancer. The prepared Microemulgel formulation was inspected visually for appearance, spreadability, homogeneity, phase separation, viscosity, pH, and Formulations were tested for drug excipient interactions subjecting to FTIR Spectral analysis and In-vitro drug diffusion studies showed 98.24% for F7 formulation maximum release of drug in 120 minutes. Topical antifungal treatment was successfully achieved with Econazole nitrate microemulgel.
