Formulation And Evaluation Of Azilsartan Nanosuspension By Solvent Evaporation Method

The current research deals with formulation and evaluation of Azilsartan nano suspension. Nanosuspension containing drug was prepared by solvent evaporation method by using combinations of SLS, Polaxomer, PVP-K25, and methanol and quantity sufficient water). The Nanosuspension were evaluated for parameters such as Entrapment efficiency, scanning electron microscopy, particle size analysis, zeta potential, in-vitro release, drug excipient interactions (FTIR). The entrapment efficacy of the formulated Nanosuspension was found to be in the range of 76.02%- 96.05% respectively. Zeta potential value for the optimized formulation (F6) was found to be within the acceptable limits. Average particle size of nanosuspension of optimized formulations (F6) was found to be 489.7nm. From the invitro studies we can say that formulation F6 shows best drug release of 98.22% within 30 minutes where as all the other formulations takes about 45-60 minutes to release the drug. The drug release from the Nanosuspension was explained by the using mathematical model equations such as zero order, first order. Based on the regression values it was concluded that the optimized formulation F6 follows First order kinetics.