Clinical Profile And Outcome Of Children With Nephrotic Syndrome

The aim of the study was to assess the clinical and demographic characteristics and management of children with nephrotic syndrome admitted to a tertiary care teaching hospital in central Kerala during aperiod of five years from Jan 2012 to Dec 2016 retrospectively. The clinical records available in the medical records at the time of data collection in 2017 were reviewed. Among the 407 children studied there was a male preponderance (61.42%). The age of children ranged from 1 month to 12 years with highest proportion in the age group 2-5 years. The children were admitted with nephrotic syndrome-15.97% as first episode 65.11% as relapse,0.98% for management of steroid resistant and17.20 %, steroid dependent nephrotic syndrome, 0.24% focal segmental glomerulo sclerosis and 0.49% congenital Nephrotic syndrome. Management of nephrotic syndrome was mainly by administration of steroids (92.63%). In cases where steroid therapy was not effective in reaching remission other drugs like levamisole (7.86%) and cyclophosphamide (1.47%), were added. Children also received antihypertensives, diuretics and intravenous albumin as support therapy in management of nephrotic syndrome.